Prion Protein Monoclonal Antibody – 2G11

REFERENCE: A03225.200 µg
Price:

$467.00

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Application

Reconstitute the content of the vial in 1 mL of water. IHC for sheep PrPres without PK treatment. For immunohistochemistry, the optimal working dilution must be determined empirically (currently between 0.1 and 1 µg/mL). Mab 2G11 binds to the partially denatured or oxidized normal prion protein in vitro and as such is an indicator (by lack of signal) of preservation of the native state.

About Bertin Pharma’s expertise:

  • 100+ assays available in various therapeutic areas.
  • Specific expertise in: Fit-to-purpose development assay, Analytical platforms (Immunoassays methods, Hyphenated methods), Biomarker Assay Translation from discovery to clinical studies, Capabilities to provide ready-to-use & customized assay kit for in-house or central labs implementation.
  • Over 20 years experience
  • Industrialisation of assays for Pharmaceutic, Cosmetic & nutraceutic laboratories.

Prion Protein (PrP) and namely its abnormal isoform, partially resistant to proteinase K (PrPres), is the only specific molecular marker of the Transmissible Spongiform Encephalopathies (TSEs) such as Bovine Spongiform Encephalopathie (BSE) or its human form, the New Variant of Creutzfeld-Jakob disease.
This antibody recognises the 149-161 peptide motif on the ovine sequence that is EDRYYRENMYRYP.

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